This box is decorated with a ladybug, which is a tessellation molecule. I used the same molecule for a BBU tile variant to make a decorated cube. While the finished molecule is axially symmetric, the underlying crease pattern is not, due to the different pleat arrangement in the body and the head. The structure is related to my Ladybug 1.1, but had to be adapted in order to become a tessellation molecule, and of course the color change had to go.
I haven’t folded a multi-molecule tessellation of this design yet, but it seems possible to make various arrangements of molecules, both ladybugs going in opposite directions, and combinations where they are rotated 90° relative to each other.